PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
Abstract
Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors. An siRNA screen of all human protein phosphatases revealed that a poorly studied protein phosphatase, PPM1H, counteracts LRRK2 signaling by specifically dephosphorylating Rab proteins. PPM1H knockout increased endogenous Rab phosphorylation and inhibited Rab...
Paper Details
Title
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
Published Date
Oct 30, 2019
Journal
Volume
8
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