The Transcriptional Repressor SmvR Is Important for Decreased Chlorhexidine Susceptibility in Enterobacter cloacae Complex

Major facilitator superfamily (MFS) efflux pumps have been shown to be important for bacterial cells to cope with biocides such as chlorhexidine (CHX), a widely used molecule in hospital settings. In this work, we evaluated the role of two genes, smvA and smvR , in CHX resistance in Enterobacter cloacae complex (ECC). smvA encodes an MFS pump whereas smvR , located upstream of smvA, codes for a TetR-type transcriptional...