A new chemotype with promise against Trypanosoma cruzi
Volume: 30, Issue: 1, Pages: 126778 - 126778
Published: Jan 1, 2020
Abstract
Pyridyl benzamide 2 is a potent inhibitor of Trypanosoma cruzi, but not other protozoan parasites, and had a selectivity-index of ≥10. The initial structure–activity relationship (SAR) indicates that benzamide and sulfonamide functional groups, and N-methylpiperazine and sterically unhindered 3-pyridyl substructures are required for high activity against T. cruzi. Compound 2 and its active analogs had low to moderate metabolic stabilities in...
Paper Details
Title
A new chemotype with promise against Trypanosoma cruzi
Published Date
Jan 1, 2020
Volume
30
Issue
1
Pages
126778 - 126778
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History