PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors.
Abstract
Intervertebral disc degeneration (IDD) is induced by multiple factors including increased apoptosis, decreased survival, and reduced extracellular matrix (ECM) synthesis in the nucleus pulposus (NP) cells. The tumor suppressor phosphatase and tensin homolog deleted from chromosome 10 (PTEN) is the only known lipid phosphatase counteracting the PI3K/AKT pathway. Loss of PTEN leads to activated PI3K/AKT signaling, which plays a key role in a...
Paper Details
Title
PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors.
Published Date
Feb 1, 2020
Journal
Volume
44
Issue
2
Pages
583 - 592
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