SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues
Abstract
CD8+ T cell responses are necessary for immune control of simian immunodeficiency virus (SIV). However, the key parameters that dictate antiviral potency remain elusive, conceivably because most studies to date have been restricted to analyses of circulating CD8+ T cells. We conducted a detailed clonotypic, functional, and phenotypic survey of SIV-specific CD8+ T cells across multiple anatomical sites in chronically infected rhesus macaques with...
Paper Details
Title
SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues
Published Date
Jan 6, 2020
Volume
130
Issue
2
Pages
789 - 798
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