Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis
Abstract
Liver kinase B1 (LKB1) is a ubiquitously expressed kinase involved in the regulation of cell metabolism, growth, and inflammatory activation. We previously reported that a single nucleotide polymorphism in the gene encoding LKB1 is a risk factor for multiple sclerosis (MS). Since astrocyte activation and metabolic function have important roles in regulating neuroinflammation and neuropathology, we examined the serine/threonine kinase LKB1 in...
Paper Details
Title
Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis
Published Date
Oct 30, 2019
Journal
Volume
68
Issue
3
Pages
600 - 616
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