Use of Nasal Pathology in the Derivation of Inhalation Toxicity Values for Hydrogen Sulfide

Nasal pathology can play an important role in the risk assessment process. For example, olfactory neuron loss (ONL) is one of the most sensitive end points seen in subchronic rodent hydrogen sulfide (H 2 S) studies and has been used by several agencies to derive health-protective toxicity values. Alternative methods that rely on computational fluid dynamics (CFD) models to account for the influence of airflow on H 2 S-induced ONL have been...