Original paper
β1-Integrin– and KV1.3 channel–dependent signaling stimulates glutamate release from Th17 cells
Abstract
Although the impact of Th17 cells on autoimmunity is undisputable, their pathogenic effector mechanism is still enigmatic. We discovered soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) complex proteins in Th17 cells that enable a vesicular glutamate release pathway that induces local intracytoplasmic calcium release and subsequent damage in neurons. This pathway is glutamine dependent and triggered by binding of β1-integrin...
Paper Details
Title
β1-Integrin– and KV1.3 channel–dependent signaling stimulates glutamate release from Th17 cells
Published Date
Jan 6, 2020
Volume
130
Issue
2
Pages
715 - 732
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Notes
History