Fundamental roles of chromatin loop extrusion in antibody class switching
Abstract
Antibody class switch recombination (CSR) in B lymphocytes replaces immunoglobulin heavy chain locus (Igh) Cμ constant region exons (CHs) with one of six CHs lying 100-200 kb downstream1. Each CH is flanked upstream by an I promoter and long repetitive switch (S) region1. Cytokines and activators induce activation-induced cytidine deaminase (AID)2 and I-promoter transcription, with 3' IgH regulatory region (3' IgHRR) enhancers controlling the...
Paper Details
Title
Fundamental roles of chromatin loop extrusion in antibody class switching
Published Date
Oct 30, 2019
Journal
Volume
575
Issue
7782
Pages
385 - 389
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