Brain Connectome Mapping of Complex Human Traits and Their Polygenic Architecture Using Machine Learning
Abstract
Background Mental disorders and individual characteristics such as intelligence and personality are complex traits sharing a largely unknown neuronal basis. Their genetic architectures are highly polygenic and overlapping, which is supported by heterogeneous phenotypic expression and substantial clinical overlap. Brain network analysis provides a noninvasive means of dissecting biological heterogeneity, yet its sensitivity, specificity, and...
Paper Details
Title
Brain Connectome Mapping of Complex Human Traits and Their Polygenic Architecture Using Machine Learning
Published Date
Apr 1, 2020
Journal
Volume
87
Issue
8
Pages
717 - 726
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