Metabolomic studies in tissues of mice treated with amifostine and exposed to gamma-radiation

Amrita K. Cheema; Yaoxiang Li; Michael Girgis; Meth Jayatilake; Madison Simas; Stephen Y. Wise; Ayodele O. Olabisi; Thomas M. Seed; Vijay K. Singh

doi:https://doi.org/10.1038/s41598-019-52120-w

doi.org/10.1038/s41598-019-52120-w

Metabolomic studies in tissues of mice treated with amifostine and exposed to gamma-radiation

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..., Vijay K. Singh

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Scientific Reports4.60

Volume: 9, Issue: 1

Published: Oct 30, 2019

Abstract

Although multiple radioprotectors are currently being investigated preclinically for efficacy and safety, few studies have investigated concomitant metabolic changes. This study examines the effects of amifostine on the metabolic profiles in tissues of mice exposed to cobalt-60 total-body gamma-radiation. Global metabolomic and lipidomic changes were analyzed using ultra-performance liquid chromatography (UPLC) quadrupole time-of-flight mass...

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Paper Details

Title

Metabolomic studies in tissues of mice treated with amifostine and exposed to gamma-radiation

DOI

doi.org/10.1038/s41598-019-52120-w

Published Date

Oct 30, 2019

Journal

Scientific Reports

Volume

9

Issue

1

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