Glucocorticoids preserve the t-tubular system in ventricular cardiomyocytes by upregulation of autophagic flux
Abstract
A major contributor to contractile dysfunction in heart failure is remodelling and loss of the cardiomyocyte transverse tubular system (t-system), but underlying mechanisms and signalling pathways remain elusive. It has been shown that dexamethasone promotes t-tubule development in stem cell-derived cardiomyocytes and that cardiomyocyte-specific glucocorticoid receptor (GR) knockout (GRKO) leads to heart failure. Here, we studied if the t-system...
Paper Details
Title
Glucocorticoids preserve the t-tubular system in ventricular cardiomyocytes by upregulation of autophagic flux
Published Date
Oct 31, 2019
Journal
Volume
114
Issue
6
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