To TRIM or not to TRIM: the balance of host–virus interactions mediated by the ubiquitin system
Abstract
The innate immune system responds rapidly to protect against viral infections, but an overactive response can cause harmful damage. To avoid this, the response is tightly regulated by post-translational modifications (PTMs). The ubiquitin system represents a powerful PTM machinery that allows for the reversible linkage of ubiquitin to activate and deactivate a target’s function. A precise enzymatic cascade of ubiquitin-activating, conjugating...
Paper Details
Title
To TRIM or not to TRIM: the balance of host–virus interactions mediated by the ubiquitin system
Published Date
Dec 1, 2019
Journal
Volume
100
Issue
12
Pages
1641 - 1662
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Notes
History