C99 selectively accumulates in vulnerable neurons in Alzheimer's disease

Volume: 16, Issue: 2, Pages: 273 - 282
Published: Jan 6, 2020
Abstract
The levels and distribution of amyloid deposits in the brain does not correlate well with Alzheimer's disease (AD) progression. Therefore, it is likely that amyloid precursor protein and its proteolytic fragments other than amyloid b (Ab) contribute to the onset of AD.We developed a sensitive assay adapted to the detection of C99, the direct precursor of b-amyloid. Three postmortem groups were studied: control with normal and stable cognition;...
Paper Details
Title
C99 selectively accumulates in vulnerable neurons in Alzheimer's disease
Published Date
Jan 6, 2020
Volume
16
Issue
2
Pages
273 - 282
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