Antibacterial properties and in vivo efficacy of a novel nitrofuran, IITR06144, against MDR pathogens

Objectives The emergence of MDR Gram-negative pathogens and increasing prevalence of chronic infections presents an unmet need for the discovery of novel antibacterial agents. The aim of this study was to evaluate the biological properties of a small molecule, IITR06144, identified in a phenotypic screen against the Gram-negative model organism Escherichia coli. Methods A small-molecule library of 10 956 compounds was screened for growth...