Original paper
Synchronized replication of genes encoding the same protein complex in fast-proliferating cells
Abstract
DNA replication perturbs the dosage balance among genes; at mid-S phase, early-replicating genes have doubled their copies while late-replicating ones have not. Dosage imbalance among genes, especially within members of a protein complex, is toxic to cells. However, the molecular mechanisms that cells use to deal with such imbalance remain not fully understood. Here, we validate at the genomic scale that the dosage between early- and...
Paper Details
Title
Synchronized replication of genes encoding the same protein complex in fast-proliferating cells
Published Date
Oct 29, 2019
Journal
Volume
29
Issue
12
Pages
1929 - 1938
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Notes
History