Assessment of DNA methylation differences between carriers of APOE ε4 and APOE ε2
Abstract
INTRODUCTIONThe Apolipoprotein E (APOE) {varepsilon}4 allele is the strongest genetic risk factor for Alzheimers disease (AD), while the {varepsilon}2 allele confers protection. Previous studies report differential DNA methylation of APOE between {varepsilon}4 and {varepsilon}2 carriers but associations with epigenome-wide methylation are unknown.nnMETHODSThe EPIC array was used to identify methylation differences between AD-free APOE...
Paper Details
Title
Assessment of DNA methylation differences between carriers of APOE ε4 and APOE ε2
Published Date
Oct 23, 2019
Journal
Pages
815035
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