P1.12-09 RNA Sequencing in Small Cell Lung Carcinoma Reveals Change in Neuroendocrine Pattern in Primary Tumor Versus Lymph Node Metastases

Recent preclinical cell line data presented at World Conference on Lung Cancer 2018 suggest that neuroendocrine (NE) pattern of small cell lung cancer (SCLC) has strong therapeutic relevance. NE high tumors are associated with immune desert and NE low tumors are considered immune oasis phenotype. Targeted RNA-sequencing of 2560 genes was performed on 32 matched surgically resected SCLC patients primary tumors and lymph node (LN) metastases. We...