7C: Computational Chromosome Conformation Capture by Correlation of ChIP-seq at CTCF motifs

Knowledge of the three-dimensional structure of the genome is necessary to understand how gene expression is regulated. Recent experimental techniques such as Hi-C or ChIA-PET measure long-range chromatin interactions genome-wide but are experimentally elaborate, have limited resolution and such data is only available for a limited number of cell types and tissues.While ChIP-seq was not designed to detect chromatin interactions, the formaldehyde...