aCLS cancers: Genomic and epigenetic changes transform the cell of origin of cancer into a tumorigenic pathogen of unicellular organization and lifestyle
Abstract
At least 1/3 of all acquired solid cancers produce unusual cyst-like structures (CLSs, PGCCs) with simultaneous loss of p53 function. However, p53 deficiency or accumulated mutations are not the causes of aCLS cancers. The cause is the reversal, to unicellularity, of a metabolic stressed cell by activating silenced transition switches and ancestral gene networks inherited from early Metazoans. After reprogramming and transformation the...
Paper Details
Title
aCLS cancers: Genomic and epigenetic changes transform the cell of origin of cancer into a tumorigenic pathogen of unicellular organization and lifestyle
Published Date
Feb 1, 2020
Journal
Volume
726
Pages
144174 - 144174
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