N‐acetylaspartate availability is essential for juvenile survival on fat‐free diet and determines metabolic health

N‐acetylaspartate (NAA) is synthesized by aspartate N ‐acetyltransferase (gene: Nat8l ) from acetyl‐coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues remained elusive. Therefore, we characterized the metabolic phenotype of knockout (ko) and adipose tissue‐specific (ako) Nat8l ‐ko mice as well as NAA‐supplemented mice on various diets. We...