Testing NTRK testing: Wet‐lab and in silico comparison of RNA‐based targeted sequencing assays
Abstract
NTRK fusions involving three neurotrophic tyrosine receptor kinase genes NTRK1, NTRK2, and NTRK3 and a variety of fusion partners were identified as oncogenic drivers across many cancer types. Drugs that target the chimeric protein product require the identification of the underlying gene fusion. This advocates the diagnostic use of molecular assays ranging from fluorescence in situ hybridization (FISH) and reverse transcription polymerase chain...
Paper Details
Title
Testing NTRK testing: Wet‐lab and in silico comparison of RNA‐based targeted sequencing assays
Published Date
Nov 18, 2019
Volume
59
Issue
3
Pages
178 - 188
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