Selection of an Efficient AAV Vector for Robust CNS Transgene Expression
Volume: 15, Pages: 320 - 332
Published: Dec 1, 2019
Abstract
Adeno-associated virus (AAV) capsid libraries have generated improved transgene delivery vectors. We designed an AAV library construct, iTransduce, that combines a peptide library on the AAV9 capsid with a Cre cassette to enable sensitive detection of transgene expression. After only two selection rounds of the library delivered intravenously in transgenic mice carrying a Cre-inducible fluorescent protein, we flow sorted fluorescent cells from...
Paper Details
Title
Selection of an Efficient AAV Vector for Robust CNS Transgene Expression
Published Date
Dec 1, 2019
Volume
15
Pages
320 - 332
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