Activity and safety of temozolomide in advanced adrenocortical carcinoma patients

Temozolomide has shown a significant anti-proliferative activity on adrenocortical cancer (ACC) cells in vitro.On the basis of these results the drug was prescribed as second/third line in advanced metastatic ACC patients in four referral centers in Italy.We retrospectively collected anagraphic, clinical and pathological data of patients with advanced ACC with disease progression to standard chemotherapy plus mitotane who were treated with...