E-Synthesis: A Bayesian Framework for Causal Assessment in Pharmacosurveillance

Background. Evidence suggesting adverse drug reactions often emerges unsystematically and unpredictably in form of anecdotal reports, case series and survey data. Safety trials and observational studies also provide crucial information regarding the (un-)safety of drugs. Hence, integrating multiple types of pharmacovigilance evidence is key to minimising the risks of harm. Methods. In previous work, we began the development of a Bayesian...