Original paper
Peptide Channeling: The Key to MHC Class I Immunosurveillance?
Abstract
The immunopeptidome presented for TCD8+ immunosurveillance on MHC class I molecules is a highly biased representation of the cellular proteome. Peptides derived from defective ribosomal products (DRiPs) have privileged access to the class I pathway over peptides generated by normal protein turnover due, at least in part, to their generation by ribosome subsets specialized for peptide generation. Cancer cells can modulate TCD8+ immunosurveillance...
Paper Details
Title
Peptide Channeling: The Key to MHC Class I Immunosurveillance?
Published Date
Dec 1, 2019
Journal
Volume
29
Issue
12
Pages
929 - 939
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Notes
History