Peptide Channeling: The Key to MHC Class I Immunosurveillance?

The immunopeptidome presented for TCD8+ immunosurveillance on MHC class I molecules is a highly biased representation of the cellular proteome. Peptides derived from defective ribosomal products (DRiPs) have privileged access to the class I pathway over peptides generated by normal protein turnover due, at least in part, to their generation by ribosome subsets specialized for peptide generation. Cancer cells can modulate TCD8+ immunosurveillance...