Original paper

Convergent in situ Generation of Both Transketolase Substrates via Transaminase and Aldolase Reactions for Sequential One‐Pot, Three‐Step Cascade Synthesis of Ketoses

Volume: 12, Issue: 3, Pages: 812 - 817
Published: Dec 19, 2019
Abstract
We describe an efficient three‐enzyme, sequential one‐pot cascade reaction where both transketolase substrates are generated in situ in a convergent fashion. The nucleophilic donor substrate hydroxypyruvate was obtained from l ‐serine and pyruvate by a transaminase‐catalyzed reaction. In parallel, three different (2 S )‐α‐hydroxylated aldehydes, l ‐glyceraldehyde, d ‐threose, and l ‐erythrose, were generated as electrophilic acceptors from...
Paper Details
Title
Convergent in situ Generation of Both Transketolase Substrates via Transaminase and Aldolase Reactions for Sequential One‐Pot, Three‐Step Cascade Synthesis of Ketoses
Published Date
Dec 19, 2019
Volume
12
Issue
3
Pages
812 - 817
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