Preadipocyte factor 1 regulates adipose tissue browning via TNF-α-converting enzyme-mediated cleavage
Abstract
Increasing adaptive thermogenesis in adipose tissue may be a potential therapeutic target for overcoming obesity and obesity-related disorders. Preadipocyte factor 1 (Pref-1), a preadipocyte secreted protein, plays an inhibitory role in adipogenic differentiation. However, the role of Pref-1 in adipose tissue browning remains unknown. We investigated whether Pref-1 regulates thermogenic program and beige fat biogenesis.Pref-1 expression levels...
Paper Details
Title
Preadipocyte factor 1 regulates adipose tissue browning via TNF-α-converting enzyme-mediated cleavage
Published Date
Dec 1, 2019
Volume
101
Pages
153977 - 153977
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