Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation
Abstract
Histones, the major protein components of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and subsequently mediate organ failure. Extracellular histones can promote endothelial damage and platelet aggregation, which can be suppressed by administration of recombinant thrombomodulin (rTM). The present study aimed to clarify whether histones can activate neutrophils to induce NET...
Paper Details
Title
Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation
Published Date
Oct 29, 2019
Journal
Volume
10
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Notes
History