Distinct tau PET patterns in atrophy‐defined subtypes of Alzheimer's disease

Introduction Differential patterns of brain atrophy on structural magnetic resonance imaging (MRI) revealed four reproducible subtypes of Alzheimer's disease (AD): (1) “typical”, (2) “limbic‐predominant”, (3) “hippocampal‐sparing”, and (4) “mild atrophy”. We examined the neurobiological characteristics and clinical progression of these atrophy‐defined subtypes. Methods The four subtypes were replicated using a clustering method on MRI data in...