Mutant GNLY is linked to Stevens–Johnson syndrome and toxic epidermal necrolysis
Abstract
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous adverse reactions to drugs. Granulysin (GNLY) plays a key role in keratinocyte apoptosis during SJS/TEN pathophysiology. To determine if GNLY-encoding mutations might be related to the protein’s functional disturbances, contributing to SJS/TEN pathogenesis, we performed direct sequencing of GNLY’s coding region in a group of 19 Colombian SJS/TEN...
Paper Details
Title
Mutant GNLY is linked to Stevens–Johnson syndrome and toxic epidermal necrolysis
Published Date
Oct 14, 2019
Journal
Volume
138
Issue
11-12
Pages
1267 - 1274
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Notes
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