Naked mole rats reduce the expression of ATP-dependent but not ATP-independent heat shock proteins in acute hypoxia

Naked mole rats (NMRs) are one of the most hypoxia-tolerant mammals identified and putatively experience intermittent and severe hypoxia in their underground burrows. Systemic physiological adaptions to hypoxia have begun to be investigated in this species; however, the cellular adaptations that underlie this tolerance remain poorly understood. Hypoxia compromises cellular energy production; and the maintenance of protein integrity when ATP...