Original paper
Vac8 spatially confines autophagosome formation at the vacuole
Abstract
Autophagy is initiated by the formation of phagophore assembly sites (PAS), the precursors of autophagosomes. In mammals, PAS form throughout the cytosol in specialized subdomains of the endoplasmic reticulum (ER). In yeast, the PAS is also generated close to the ER, but always in the vicinity of the vacuole. How the PAS is anchored to the vacuole and the functional significance of this localization are unknown. Here, we investigated the role of...
Paper Details
Title
Vac8 spatially confines autophagosome formation at the vacuole
Published Date
Jan 1, 2019
Journal
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Notes
History