MLH1 deficiency leads to deregulated mitochondrial metabolism
Abstract
The DNA mismatch repair (MMR) pathway is responsible for the repair of base–base mismatches and insertion/deletion loops that arise during DNA replication. MMR deficiency is currently estimated to be present in 15–17% of colorectal cancer cases and 30% of endometrial cancers. MLH1 is one of the key proteins involved in the MMR pathway. Inhibition of a number of mitochondrial genes, including POLG and PINK1 can induce synthetic lethality in...
Paper Details
Title
MLH1 deficiency leads to deregulated mitochondrial metabolism
Published Date
Oct 22, 2019
Journal
Volume
10
Issue
11
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