Formulation buoyancy of nanoencapsulated gliclazide using primary, conjugated and deconjugated bile acids
Abstract
Aim: Recent studies suggest potential applications of endogenously produced human bile acids as formulation-excipient and drug tissue permeation enhancers in Type 1 diabetes. We aimed to examine the stability, tissue permeation and ex vivo muscle-cell effects of microencapsulated gliclazide (G) incorporated with a primary (chenodeoxycholic acid [CDCA]), a secondary (ursodeoxycholic acid [UDCA]) or a tertiary (taurocholic acid [TCA]) bile acid....
Paper Details
Title
Formulation buoyancy of nanoencapsulated gliclazide using primary, conjugated and deconjugated bile acids
Published Date
Sep 1, 2019
Journal
Volume
10
Issue
9
Pages
573 - 583
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Notes
History