1553. Human-Simulated Pharmacokinetic Profiles of Cefiderocol and Meropenem Are Conserved in Murine Models of Thigh Infection With or Without Iron Overload

Background A translational murine model of thigh infection with comorbid iron overload was previously developed to study the efficacy of iron-dependent siderophore-antibiotic conjugates under conditions where the hypoferremic response of innate immunity may be compromised. Given the potential for functional organ damage from excessive tissue iron, which could alter the pharmacokinetic (PK) profiles of antibiotics being compared for efficacy...