Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion
Abstract
The aggressive brain tumor glioblastoma (GBM) is characterized by rapid cellular infiltration of brain tissue, raising the possibility that disease progression could potentially be slowed by disrupting the machinery of cell migration. The LIM kinase isoforms LIMK1 and LIMK2 (LIMK1/2) play important roles in cell polarization, migration, and invasion and are markedly upregulated in GBM and many other infiltrative cancers. Yet, it remains unclear...
Paper Details
Title
Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion
Published Date
Jan 1, 2020
Journal
Volume
80
Issue
1
Pages
69 - 78
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