TGF-β signaling is critical for maintenance of the tendon cell fate
Abstract
Studies of cell fate focus on specification, but little is known about maintenance of the differentiated state. We find that TGF{beta} signaling plays an essential role in maintenance of the tendon cell fate. To examine the role TGF{beta} signaling in tenocytes TGF{beta} type II receptor was targeted in the Scleraxis cell lineage. Tendon development was not disrupted in mutant embryos, but shortly after birth tenocytes lost differentiation...
Paper Details
Title
TGF-β signaling is critical for maintenance of the tendon cell fate
Published Date
Oct 29, 2019
Journal
Pages
823021
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