TGF-β signaling is critical for maintenance of the tendon cell fate

Pages: 823021
Published: Oct 29, 2019
Abstract
Studies of cell fate focus on specification, but little is known about maintenance of the differentiated state. We find that TGF{beta} signaling plays an essential role in maintenance of the tendon cell fate. To examine the role TGF{beta} signaling in tenocytes TGF{beta} type II receptor was targeted in the Scleraxis cell lineage. Tendon development was not disrupted in mutant embryos, but shortly after birth tenocytes lost differentiation...
Paper Details
Title
TGF-β signaling is critical for maintenance of the tendon cell fate
Published Date
Oct 29, 2019
Journal
Pages
823021
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