The landscape of somatic mutation in normal colorectal epithelial cells
Abstract
The colorectal adenoma-carcinoma sequence has provided a paradigmatic framework for understanding the successive somatic genetic changes and consequent clonal expansions that lead to cancer1. However, our understanding of the earliest phases of colorectal neoplastic changes-which may occur in morphologically normal tissue-is comparatively limited, as for most cancer types. Here we use whole-genome sequencing to analyse hundreds of normal crypts...
Paper Details
Title
The landscape of somatic mutation in normal colorectal epithelial cells
Published Date
Oct 23, 2019
Journal
Volume
574
Issue
7779
Pages
532 - 537
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