Original paper
Inhibiting repressive epigenetic modification promotes telomere rejuvenation in somatic cell reprogramming
Abstract
The efficiency of somatic cell nuclear transfer (SCNT) reprogramming is extremely low in terms of production of cloned animals. Here, we found that telomere rejuvenation is a critical event for SCNT reprogramming. Through small-molecule screening, we identified that melatonin significantly improved the in vitro and in vivo developmental competence of SCNT-derived embryos. Through use of embryonic biopsy, single-cell RNA sequencing, and...
Paper Details
Title
Inhibiting repressive epigenetic modification promotes telomere rejuvenation in somatic cell reprogramming
Published Date
Oct 23, 2019
Journal
Volume
33
Issue
12
Pages
13982 - 13997
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History