GroEL Allostery Illuminated by a Relationship between the Hill Coefficient and the MWC Model
Abstract
A fundamental problem that has hindered the use of the classic Monod-Wyman-Changuex (MWC) allosteric model since its introduction is that it has been difficult to determine the values of its parameters in a reliable manner because they are correlated with each other and sensitive to the data-fitting method. Consequently, experimental data are often fitted to the Hill equation, which provides a measure of cooperativity but no insights into its...
Paper Details
Title
GroEL Allostery Illuminated by a Relationship between the Hill Coefficient and the MWC Model
Published Date
Nov 1, 2019
Journal
Volume
117
Issue
10
Pages
1915 - 1921
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