Structure of a P element transposase–DNA complex reveals unusual DNA structures and GTP-DNA contacts

Volume: 26, Issue: 11, Pages: 1013 - 1022
Published: Oct 28, 2019
Abstract
P element transposase catalyzes the mobility of P element DNA transposons within the Drosophila genome. P element transposase exhibits several unique properties, including the requirement for a guanosine triphosphate cofactor and the generation of long staggered DNA breaks during transposition. To gain insights into these features, we determined the atomic structure of the Drosophila P element transposase strand transfer complex using cryo-EM....
Paper Details
Title
Structure of a P element transposase–DNA complex reveals unusual DNA structures and GTP-DNA contacts
Published Date
Oct 28, 2019
Volume
26
Issue
11
Pages
1013 - 1022
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