Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss
Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition that primarily affects the motor system and shares many features with frontotemporal dementia (FTD). Evidence suggests that ALS is a 'dying-back' disease, with peripheral denervation and axonal degeneration occurring before loss of motor neuron cell bodies. Distal to a nerve injury, a similar pattern of axonal degeneration can be seen, which is mediated by an active axon...
Paper Details
Title
Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss
Published Date
Oct 28, 2019
Volume
7
Issue
1
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