Metabolomic profiles associated with all-cause mortality in the Women’s Health Initiative

Background Metabolomics profiling has shown promise in elucidating the biological pathways underpinning mortality, but there are limited data in female populations. Methods We applied a liquid chromatography-tandem mass spectrometry metabolomics platform to EDTA-plasma to measure 470 metabolites at baseline in a discovery set of 943 postmenopausal women (including 417 incident deaths, median time to death of 10.6 years) with validation in an...