Persistence of oral anticoagulant treatment for atrial fibrillation in the Netherlands: A surveillance study

In contrast to vitamin K antagonists (VKA), direct oral anticoagulants (DOAC's) are not strictly monitored and dose titrated by anticoagulation clinics in the Netherlands. This may affect drug persistence of atrial fibrillation (AF) patients, whom often require lifelong treatment.To assess persistence of DOACs and of VKAs in patients with AF.Dispensing data from the Dutch Foundation of Pharmaceutical Statistics were used to monitor persistence...