O4-04-04: PIB(+) CHRONICITY PROVIDES UNIQUE INFORMATION ABOUT COGNITIVE DECLINE AND NFT DEVELOPMENT: RESULTS FROM THE WISCONSIN REGISTRY FOR ALZHEIMER'S PREVENTION

Amyloid PET provides an indicator of how much amyloid pathology is present at any given time but longitudinal models are needed to gauge amyloid chronicity. We recently identified distinct longitudinally-based patterns of PiB accumulation in a late middle-aged AD risk-enriched cohort which allow us to estimate duration of detectable amyloid at time of other assessments. In this study, we examined whether years PiB(+) was associated with...