Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrum
Abstract
Stress granules (SGs) are dynamic membraneless compartments composed out of RNA-binding proteins (RBPs) and RNA molecules that assemble temporarily to allow the cell to cope with cellular stress by stalling mRNA translation and moving synthesis towards cytoprotective proteins. Aberrant SGs have become prime suspects in the nucleation of toxic protein aggregation in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Perturbed...
Paper Details
Title
Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrum
Published Date
Feb 1, 2020
Journal
Volume
134
Pages
104639 - 104639
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