Public Endowment of B Cells

Using a transgenic mouse strain expressing the human VH1-69 germline gene used by many broadly neutralizing antibodies to influenza A virus, Sangesland et al. show that the VH1-69 gene segment provides the essentials for mounting antibody responses against the conserved hemagglutinin stem epitope. Using a transgenic mouse strain expressing the human VH1-69 germline gene used by many broadly neutralizing antibodies to influenza A virus,...