Pathological high frequency oscillations associate with increased GABA synaptic activity in pediatric epilepsy surgery patients

Carlos Cepeda; Simon Levinson; Hiroki Nariai; Vannah Wila Yazon; Conny H Tran; Joshua Barry; Katerina D. Oikonomou; Harry V. Vinters; Aria Fallah; Gary W. Mathern

doi:https://doi.org/10.1016/j.nbd.2019.104618

doi.org/10.1016/j.nbd.2019.104618

Pathological high frequency oscillations associate with increased GABA synaptic activity in pediatric epilepsy surgery patients

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..., Gary W. Mathern

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Neurobiology of Disease6.10

Volume: 134, Pages: 104618 - 104618

Published: Feb 1, 2020

Abstract

Pathological high-frequency oscillations (HFOs), specifically fast ripples (FRs, >250 Hz), are pathognomonic of an active epileptogenic zone. However, the origin of FRs remains unknown. Here we explored the correlation between FRs recorded with intraoperative pre-resection electrocorticography (ECoG) and spontaneous synaptic activity recorded ex vivo from cortical tissue samples resected for the treatment of pharmacoresistant epilepsy. The...

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Paper Details

Title

Pathological high frequency oscillations associate with increased GABA synaptic activity in pediatric epilepsy surgery patients

DOI

doi.org/10.1016/j.nbd.2019.104618

Published Date

Feb 1, 2020

Journal

Neurobiology of Disease

Volume

134

Pages

104618 - 104618

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