Disease Severity Linked to Increase in Autoantibody Diversity in IgG4‐Related Disease

Objective Four autoantigens have been described recently in IgG4‐related disease (IgG4‐ RD ): prohibitin, annexin A11, laminin 511‐E8, and galectin‐3. However, no external validation has been performed, and the possibility that some individuals break tolerance to more than 1 autoantigen has not been explored. We undertook this study to evaluate the relative frequencies of antibody responses against these autoantigens in order to explore the role...